Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo

Background: Use of ultra-high diluted remedies in homeopathy and their claimed efficacy curing diseases has been challenged time again by non-believers despite many evidence-based positive results published favor curing/ameliorating disease symptoms. Aims: To test the ability homeopathic beyond Avogadro’s limit, if any, manifesting gene modulating effects controlled vitro experimental model. Methods: Since cancer cells manifest aberrant epigenetic expressions, we conducted global microarray expression profiling HeLa (an established model HPV18 cell line) treated with two different potentized remedies, namely, Condurango 30c Hydrastis canadensis 30C (used treatment cancer), as compared to that placebo (succussed alcohol 30c). Results: Data revealed distinctly patterns over 100 genes a consequence both homeopathc placebo. Conclusion: Results indicate action drugs was “more than placebo” these ultra-highly acted primarily through modulation expression.